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Sco2tm1.1Easc
Targeted Allele Detail
Nomenclature
Symbol: Sco2tm1.1Easc
Name: SCO2 cytochrome c oxidase assembly protein; targeted mutation 1.1, Eric A Schon
MGI ID: MGI:4413584
Synonyms: Sco2loxPKO
Gene: Sco2  Location: Chr15:89371639-89373818 bp, - strand  Genetic Position: Chr15, 44.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155116
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted 30 bp downstream of the translation initiation site. Cre mediated recombination removed the neo cassette leaving a single loxP site. The absence of COX activity was confirmed in E8.5 embryos. (J:155116)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sco2 Mutation:  2 strains or lines available
References
Original:  J:155116 Yang H, et al., Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet. 2010 Jan 1;19(1):170-80
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory