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Targeted Allele Detail
Symbol: Afp/Albtm1.1Brts
Name: albumin; targeted mutation 1.1, Brett T Spear
MGI ID: MGI:4413476
Synonyms: enh-
Gene: Alb  Location: Chr5:90460897-90476602 bp, + strand  Genetic Position: Chr5, 44.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:154917
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThree enhancers between the genes were replaced with a floxed neo cassette. Cre mediated recombination removed the neo cassette. Early transcript expression of Alb and Afp is reduced, as confirmed by whole mount in situ hybridization on E10.5 embryos. (J:154917)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alb Mutation:  34 strains or lines available
Original:  J:154917 Jin L, et al., The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development. Dev Biol. 2009 Dec 15;336(2):294-300
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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