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Grik4tm1.1Sfh
Targeted Allele Detail
Nomenclature
Symbol: Grik4tm1.1Sfh
Name: glutamate receptor, ionotropic, kainate 4; targeted mutation 1.1, Stephen F Heinemann
MGI ID: MGI:4413475
Synonyms: GluK4-
Gene: Grik4  Location: Chr9:42518135-42944493 bp, - strand  Genetic Position: Chr9, 23.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155003
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 14 and a floxed neo cassette was inserted downstream of exon 14. Cre mediated recombination removed exon 14. The absence of protein expression was confirmed by western blot analysis on hippocampus extracts. (J:155003)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik4 Mutation:  10 strains or lines available
References
Original:  J:155003 Fernandes HB, et al., High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron. 2009 Sep 24;63(6):818-29
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory