Rr92^tm1.1Brts
Targeted Allele Detail

Summary

• Symbol: Rr92^tm1.1Brts
• Name: regulatory region 92; targeted mutation 1.1, Brett T Spear
• MGI ID: MGI:4413473
• Synonyms: Afp/Alb^tm1.1Brts, enh^-
• Gene: Rr92 Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Rr92^tm1.1Brts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154917
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Three enhancers between the Alb and Afp genes were replaced with a loxP site flanked neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette. Early transcript expression of Alb and Afp is reduced, as confirmed by whole mount in situ hybridization on E10.5 embryos. (J:154917)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr92 Mutation: 0 strains or lines available

References

• Original: J:154917 Jin L, et al., The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development. Dev Biol. 2009 Dec 15;336(2):294-300
• All: 1 reference(s)