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Targeted Allele Detail
Symbol: Islr2tm1.1Ddg
Name: immunoglobulin superfamily containing leucine-rich repeat 2; targeted mutation 1.1, David D Ginty
MGI ID: MGI:4413447
Synonyms: LinxtEGFP
Gene: Islr2  Location: Chr9:58196297-58204319 bp, - strand  Genetic Position: Chr9, 31.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:154926
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 3 was replaced with Tau (Mapt)/EGFP fusion, a polyadenylation sequence, and floxed neo cassette. Germ line, cre mediated recombination removed the neo cassette. Reduced protein expression was confirmed by western blot analysis on brain extracts. (J:154926)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Islr2 Mutation:  20 strains or lines available
Original:  J:154926 Mandai K, et al., LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009 Sep 10;63(5):614-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory