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Gene trapped Allele Detail
Symbol: Nkain4Gt(M076C04)Vmel
Name: Na+/K+ transporting ATPase interacting 4; gene trap M076C04, Harald von Melchner
MGI ID: MGI:4413343
Gene: Nkain4  Location: Chr2:180934772-180954699 bp, - strand  Genetic Position: Chr2, 103.53 cM, cytoband H4
Mutant Cell Line:  M076C04 (Harald von Melchner)
Germline Transmission:  Earliest citation of germline transmission: J:154726
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: U3CEO     Vector Type: secretory trap
Mutation detailsThe first intron of the endogenous gene is interrupted by the U3Ceo secretory gene trap vector. This vector comprises an enhancerless, promoterless Moloney mouse leukemia (retro)virus genome whose LTR U3 region contains the Ceo fusion gene, which encodes a protein joining the promoterless type II transmembrane and extracellular domains of human CD2 to bacterial neomycin phosphotransferase; the CD2-encoding DNA segment includes a cryptic splice acceptor site. Expression of the endogenous gene is undetectable by northern blot analysis of total brain RNA from homozygous mutant mice. (J:154726)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkain4 Mutation:  15 strains or lines available
Original:  J:154726 De-Zolt S, et al., High-throughput trapping of secretory pathway genes in mouse embryonic stem cells. Nucleic Acids Res. 2006;34(3):e25
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.08
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