Foxc2^tm1.1Sven
Targeted Allele Detail

Summary

• Symbol: Foxc2^tm1.1Sven
• Name: forkhead box C2; targeted mutation 1.1, Sven Enerback
• MGI ID: MGI:4412379
• Synonyms: Foxc2nLacZ
• Gene: Foxc2 Location: Chr8:121842910-121845634 bp, + strand Genetic Position: Chr8, 70.33 cM
• Alliance: Foxc2^tm1.1Sven page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155032
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ gene with a nuclear localization signal was inserted 17 codons downstream of the translation initiation site to create an in frame fusion. This insertion deletes all but the first 17 codons of the coding region. Transient cre expression in ES cells removes the floxed neo cassette downstream of the lacZ gene. (J:155032)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxc2 Mutation: 15 strains or lines available

References

• Original: J:155032 Cederberg A, et al., In vitro differentiated adipocytes from a Foxc2 reporter knock-in mouse as screening tool. Transgenic Res. 2009 Dec;18(6):889-97
• All: 2 reference(s)