Tg(TetO-Nfkbia*S32A*S36A)1Wcg
Transgene Detail

Summary

• Symbol: Tg(TetO-Nfkbia*S32A*S36A)1Wcg
• Name: transgene insertion 1, Warner C Greene
• MGI ID: MGI:4412273
• Synonyms: Tet-O-IkappaBalpha-SR
• Transgene: Tg(TetO-Nfkbia*S32A*S36A)1Wcg Location: unknown
• Alliance: Tg(TetO-Nfkbia*S32A*S36A)1Wcg page

Transgene origin

• Strain of Origin: DBA

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The Nfkbia gene containing two mutations causing Serine to Alanine changes at codons 32 and 36 (supperrepressor or -SR) was placed under the control of the TetO promoter. Eight founder lines were developed. (J:112973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:112973 O'Mahony A, et al., NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity. Mol Cell Biol. 2006 Oct;26(19):7283-98
• All: 1 reference(s)