Ndp^tm1.1Nat
Targeted Allele Detail

Summary

• Symbol: Ndp^tm1.1Nat
• Name: Norrie disease (pseudoglioma) (human); targeted mutation 1.1, Jeremy Nathans
• MGI ID: MGI:4412060
• Synonyms: Ndp^AP
• Gene: Ndp Location: ChrX:16751760-16778013 bp, - strand Genetic Position: ChrX, 12.07 cM
• Alliance: Ndp^tm1.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154020
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An alkaline phosphatase sequence was inserted in exon2 along with an frt flanked PGK-neomycin cassette. Excision of the PGK-neo cassette was accomplished by crossing mice to Tg(ACTFLPe)9205Dym. (J:154020)

Expression

In Mice Carrying this Mutation:

61 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndp Mutation: 7 strains or lines available

References

• Original: J:154020 Ye X, et al., Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell. 2009 Oct 16;139(2):285-98
• All: 4 reference(s)