Tg(Grm6-icre)1Rlbn
Transgene Detail

Summary

• Symbol: Tg(Grm6-icre)1Rlbn
• Name: transgene insertion 1, R Lane Brown
• MGI ID: MGI:4411993
• Synonyms: mGluR6-Cre
• Transgene: Tg(Grm6-icre)1Rlbn Location: unknown
• Alliance: Tg(Grm6-icre)1Rlbn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Grm6-icre)1Rlbn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grm6 (MGI:1351343)

• Mutation details: The transgenic construct contains a 637-bp Grm6 (mGluR6) promoter fragment upstream of a codon-improved cre (iCre) and a polyadenylation sequence. A 9.5 kb fragment of the Grm6 5' upstream region was inserted to reconstitute the full-length Grm6 promoter. The construct was injected into fertilized oocytes and two founder lines were obtained. Only one line was found to express cre in the retina. (J:154776)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grm6 (mouse) Summary of all recombinase alleles driven by Grm6. Comparative matrix view of recombinase activities Alliance mouse Grm6 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:154776 Morgans CW, et al., TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19174-8
• All: 3 reference(s)