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Rnf103tm1.1Thg
Targeted Allele Detail
Nomenclature
Symbol: Rnf103tm1.1Thg
Name: ring finger protein 103; targeted mutation 1.1, Tamotsu Hashimoto-Gotoh
MGI ID: MGI:4410507
Synonyms: kf-1-
Gene: Rnf103  Location: Chr6:71493894-71510881 bp, + strand  Genetic Position: Chr6, 32.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154853
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector contains a diphtheria toxin cassette, a neo cassette in reverse orientation inserted 3' to exon 4 and loxP sites flanking the neo cassette and exon 4. Exon 4 includes coding sequences for the transmembrane regions, the ubiquitination site and zinc finger binding domain. Mice were crossed with mice carrying Tg(CAG-cre)12Miya to remove exon 4 and the neo cassette leaving a single loxP site downstream of exon 3. Protein was not detectable by Western blot and immunochemistry analyses. (J:154853)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rnf103 Mutation:  4 strains or lines available
References
Original:  J:154853 Tsujimura A, et al., Mice Lacking the kf-1 Gene Exhibit Increased Anxiety- but not Despair-Like Behavior. Front Behav Neurosci. 2008;2:4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory