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Tg(CAG-CYP27A1)23Etl
Transgene Detail
Nomenclature
Symbol: Tg(CAG-CYP27A1)23Etl
Name: transgene insertion 23, Eran Leitersdorf
MGI ID: MGI:4410298
Synonyms: CYP27overexp
Transgene: Tg(CAG-CYP27A1)23Etl  Location: unknown  
Transgene
origin
Strain of Origin:  CBA
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-CYP27A1)23Etl expresses 1 gene
 
Mutation detailsThe transgene construct has the human cytomegalovirus immediate early promoter enhancer with chicken beta-actin/rabbit beta-globin hybrid promoter (CAG; from the pCAGGS vector) driving expression of a 1.8 kb fragment encoding the human CYP27A1 (cytochrome P450, family 27, subfamily A, polypeptide 1) cDNA sequence. This transgene was microinjected into the pronuclei of fertilized mouse eggs taken from superovulated CBA females. The highest transgenic overexpressor founder mouse (23) was bred to wildtype C57BL/6J (Harlan) mice to establish line 23. (J:78951)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:78951 Meir K, et al., Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. J Biol Chem. 2002 Sep 13;277(37):34036-41
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory