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Gt(ROSA)26Sortm4(CAG-hsb5)Nki
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm4(CAG-hsb5)Nki
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, The Netherlands Cancer Institute
MGI ID: MGI:4410291
Synonyms: Rosa26flox-SB, Rosa26Lox66SBLox71
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172071
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Transposase)
Mutation:    Insertion
 
Mutation detailsAn inverted cassette containing a hyperactive sleeping beauty transposase variant hsb5 under the control of the CAG promoter flanked lox66 and lox71 sites was cloned into the Gt(Rosa)26Sor locus. (J:172071, J:178629)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  431 strains or lines available
References
Original:  J:172071 Vassiliou GS, et al., Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet. 2011 May;43(5):470-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory