Esrp2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Esrp2^{tm1(KOMP)Vlcg}
• Name: epithelial splicing regulatory protein 2; targeted mutation 1, Velocigene
• MGI ID: MGI:4399676
• Gene: Esrp2 Location: Chr8:106856951-106863606 bp, - strand Genetic Position: Chr8, 53.1 cM
• Alliance: Esrp2^{tm1(KOMP)Vlcg} page
• IMPC: Esrp2 gene page

Mutation origin

• Mutant Cell Lines: 13762A-B2, 13762A-F3, 13762A-F9, 13762A-F10, 13762A-G3, 13762A-H9
• Germline Transmission: Earliest citation of germline transmission: J:228040
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 5348bp between positions 106858049-106863396 of Chromosome 8 (Build GRCm39). qRT-PCR and Western blot analysis confirmed complete loss of mRNA and protein expression in the liver of homozygotes. (J:136110, J:228040)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Esrp2 Mutation: 26 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 7 reference(s)