Cldn12^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Cldn12^{tm1(KOMP)Vlcg}
• Name: claudin 12; targeted mutation 1, Velocigene
• MGI ID: MGI:4399532
• Gene: Cldn12 Location: Chr5:5555015-5564976 bp, - strand Genetic Position: Chr5, 2.98 cM, cytoband A1
• Alliance: Cldn12^{tm1(KOMP)Vlcg} page
• IMPC: Cldn12 gene page

Mutation origin

• Mutant Cell Lines: 13208A-A6, 13208A-E2, 13208A-F12, 13208A-H5
• Germline Transmission: Earliest citation of germline transmission: J:279934
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 760bp between positions 5557663-5558422 of Chromosome 5 (Build GRCm39). This deletion replaces the entire coding sequence residing only within exon 5 with a lacZ cassette and a loxP flanked neomycin-selection cassette. The deletion includes 28 bps upstream of the translational start site and 21 bps downstream of the stop codon. (J:136110, J:279934)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 1 line available
• Carrying any Cldn12 Mutation: 21 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 6 reference(s)