P3h3^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: P3h3^{tm1(KOMP)Vlcg}
• Name: prolyl 3-hydroxylase 3; targeted mutation 1, Velocigene
• MGI ID: MGI:4399383
• Gene: P3h3 Location: Chr6:124818052-124834680 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: P3h3^{tm1(KOMP)Vlcg} page
• IMPC: P3h3 gene page

Mutation origin

• Mutant Cell Lines: 12611A-B3, 12611A-B7, 12611A-E10, 12611A-F5
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 16024bp between positions 124818624-124834647 of Chromosome 6 (Build GRCm39). (J:136110)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any P3h3 Mutation: 46 strains or lines available

Notes

Cell line 12611a-F5 was successfully used to make chimeric mice. Germline transmission was accomplished. J:240600

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 4 reference(s)