Tg(Myh6-Gata4)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6-Gata4)1Jmol
• Name: transgene insertion 1, Jeffery D Molkentin
• MGI ID: MGI:4399083
• Transgene: Tg(Myh6-Gata4)1Jmol Location: unknown
• Alliance: Tg(Myh6-Gata4)1Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Gata4)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gata4 (MGI:95664)

• Mutation details: The GATA binding protein 4 (Gata4) sequence driven by myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6 or alpha-MHC) promoter/enhancer elements. One founder with 15-20 transgenic insertions died within 4 weeks of severe cardiomyopathy. This line was derived from a founder with only 1-3 insertions. Gata4 expression in the heart was increased 2.5 fold. (J:128831)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128831 Liang Q, et al., The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem. 2001 Aug 10;276(32):30245-53
• All: 2 reference(s)