Gdf15^tm1Kuns
Targeted Allele Detail

Summary

• Symbol: Gdf15^tm1Kuns
• Name: growth differentiation factor 15; targeted mutation 1, Klaus Unsicker
• MGI ID: MGI:4399064
• Synonyms: GDF-15^lacZ, GDF-15^-lacZknockin
• Gene: Gdf15 Location: Chr8:71082043-71085106 bp, - strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Gdf15^tm1Kuns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154446
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ reporter gene and a pgk-neo cassette replaced the entire protein-coding sequence of the gene through homologous recombination. Western blot analysis of kidney protein extracts confirmed the absence of protein expression in the homozygous mice. (J:154446)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf15 Mutation: 26 strains or lines available

References

• Original: J:154446 Strelau J, et al., Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci. 2009 Oct 28;29(43):13640-8
• All: 8 reference(s)