Gt(ROSA)26Sor^{tm2(CMV-Bmi1)Nki}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CMV-Bmi1)Nki}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, The Netherlands Cancer Institute
• MGI ID: MGI:4398914
• Synonyms: Bmi1^Lox66/Lox71, Bmi-CTI, Gt(ROSA)26Sor^{tm2(CMV-Bmi1,EGFP)Nki}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CMV-Bmi1)Nki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: The targeting construct contains a CMV promoter followed by a LoxP66 site, a cDNA encoding an antisense mouse Bmi1, an IRES, an eGFP cassette and a LoxP71 followed by a PGK promoter neo cassette. Cre expression enables the inversion of the antisense Bmi1. (J:187257)

Schematic of the Gt(ROSA)26Sor^tm2(CMV-Bmi1)Nki allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1096 strains or lines available

References

• Original: J:187257 Westerman BA, et al., GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors. PLoS One. 2012;7(5):e35943
• All: 1 reference(s)