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Acvrl1tm2.1Spo
Targeted Allele Detail
Nomenclature
Symbol: Acvrl1tm2.1Spo
Name: activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
MGI ID: MGI:4398901
Synonyms: Alk11f/2f, Alk12loxP
Gene: Acvrl1  Location: Chr15:101128522-101145336 bp, + strand  Genetic Position: Chr15, 56.41 cM, cytoband F3
Arteriovenous malformations in the brain, lung, and GI tract of Acvrl1tm2.1Spo/Acvrl1tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice

Show the 10 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130020
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Germ line, cre mediated recombination removed the neo cassette leaving exons 4 through 6 floxed. (J:130020)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvrl1 Mutation:  12 strains or lines available
References
Original:  J:130020 Park SO, et al., ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood. 2008 Jan 15;111(2):633-42
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory