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Targeted Allele Detail
Symbol: Acvrl1tm2.1Spo
Name: activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
MGI ID: MGI:4398901
Synonyms: Alk11f/2f, Alk12loxP
Gene: Acvrl1  Location: Chr15:101128522-101145336 bp, + strand  Genetic Position: Chr15, 56.41 cM, cytoband F3
Endothelial Alk1 deletion from the Acvrl1tm2.1Spo allele resulted in postnatal lethality by P5, with areteriovenous malformations in the brain, lung, and GI tract

Show the 10 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:130020
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Germ line, cre mediated recombination removed the neo cassette leaving exons 4 through 6 floxed. (J:130020)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvrl1 Mutation:  8 strains or lines available
Original:  J:130020 Park SO, et al., ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood. 2008 Jan 15;111(2):633-42
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory