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Hbegftm1Hhar
Targeted Allele Detail
Nomenclature
Symbol: Hbegftm1Hhar
Name: heparin-binding EGF-like growth factor; targeted mutation 1, Hideaki Hara
MGI ID: MGI:4398735
Gene: Hbegf  Location: Chr18:36504927-36515805 bp, - strand  Genetic Position: Chr18, 19.46 cM
Morphological changes in the prefrontal cortex of Hbegftm1Hhar/Hbegftm1Hhar Tg(Six3-cre)69Frty/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154094
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe full length cDNA, including poly A site was flanked by lox P sites and followed by a LacZ reporter, and replaced exons 1-3. A neo cassette driven by phosphoglycerate kinase promoter and the diphtheria toxinA fragment (DT-A) was placed within intron 3. sequence. (J:154094)
Generation of the Hbegftm1Hhar allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbegf Mutation:  18 strains or lines available
References
Original:  J:154094 Oyagi A, et al., Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice. PLoS One. 2009;4(10):e7461
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory