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Sox2tm4.1Skn
Targeted Allele Detail
Nomenclature
Symbol: Sox2tm4.1Skn
Name: SRY (sex determining region Y)-box 2; targeted mutation 4.1, Silvia K Nicolis
MGI ID: MGI:4397705
Synonyms: Sox2fl, Sox2loxPdeltaneo
Gene: Sox2  Location: Chr3:34650405-34652461 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154650
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the coding region and an frt flanked neo cassette with a 5' loxP site was inserted downstream of the coding regon. Germ line, flp mediated recombination removed the neo cassette leaving the coding region floxed. (J:154650)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:  20 strains or lines available
References
Original:  J:154650 Favaro R, et al., Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci. 2009 Oct;12(10):1248-56
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory