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Cngb3tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Cngb3tm1Dgen
Name: cyclic nucleotide gated channel beta 3; targeted mutation 1, Deltagen
MGI ID: MGI:4367989
Gene: Cngb3  Location: Chr4:19280850-19510623 bp, + strand  Genetic Position: Chr4, 7.42 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154304
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe sequence from bases 733 to 749 of the transcript (GenBank accession number AJ243572) were removed by targeted deletion. The absence of protein expression was confirmed by immunofluorescence labeling of retinal sections. (J:154304)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cngb3 Mutation:  26 strains or lines available
References
Original:  J:154304 Ding XQ, et al., Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism. Hum Mol Genet. 2009 Dec 15;18(24):4770-4780
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory