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Tg(Slc6a4-cre/ERT2)EZ13Gsat
Transgene Detail
Nomenclature
Symbol: Tg(Slc6a4-cre/ERT2)EZ13Gsat
Name: transgene insertion EZ13, GENSAT Project at Rockefeller University
MGI ID: MGI:4367233
Synonyms: Founder Line EZ13, Tg(Slc6a4-cre/Esr1)13Gsat
Transgene: Tg(Slc6a4-cre/ERT2)EZ13Gsat  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Project Collection: GENSAT
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThis transgene contains the coding sequence for the Cre-ERT2 fusion protein, followed by a polyadenylation signal, inserted into a mouse genomic artificial chromosome (BAC) at the ATG transcription initiation codon of the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 gene so that expression of the tamoxifen-activated recombinase is driven by the regulatory sequences of the mouse gene. ERT2 is a triply mutated (G400V, M543A, L544A) human estrogen receptor ligand-binding domain that renders the fusion protein highly sensitive to activation by 4-hydroxytamoxifen, but unresponsive to the receptor's native ligands. (J:100256, J:145100)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc6a4     Summary of all recombinase alleles driven by Slc6a4. Comparative matrix view of recombinase activities
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:100256 The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY), MGI download of GENSAT transgene data. Database Download. 2005;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory