About   Help   FAQ
TgTn(sb-T2/Onc3)12740Njen
Transgene Detail
Nomenclature
Symbol: TgTn(sb-T2/Onc3)12740Njen
Name: transgenic transposon concatemer 12740, Nancy A Jenkins
MGI ID: MGI:4367093
Synonyms: T2/Onc3, T2Onc3(12740), TG12740
Transgene: TgTn(sb-T2/Onc3)12740Njen  Location: unknown  Genetic Position: Chr9, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Transposon concatemer)
Mutation:    Insertion
 
Mutation detailsA concatemer of sleeping beauty transposable elements each consisting of optimized inverted repeat direct repeat sequence specific for sleeping beauty transposase flanking splice acceptor sites (from engrailed-2) and poly A signals in both orientations. Between the splice acceptor sites is the sequence for the CAG promoter followed by a splice donor site. Two lines were created (lines 12740 and 12775) with 11 and 28 copies of the transgenic transposon concatemer inserted into chromosome 9 and 12, respectively. Line 12740 was selected as the representative line. (J:153656)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:153656 Dupuy AJ, et al., A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res. 2009 Oct 15;69(20):8150-6
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/10/2020
MGI 6.16
The Jackson Laboratory