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Transgene Detail
Symbol: TgTn(sb-T2/Onc3)12740Njen
Name: transgenic transposon concatemer 12740, Nancy A Jenkins
MGI ID: MGI:4367093
Synonyms: T2/Onc3, T2Onc3(12740), TG12740
Transgene: TgTn(sb-T2/Onc3)12740Njen  Location: unknown  Genetic Position: Chr9, Syntenic
Strain of Origin:  (C57BL/6J x C3H)F1
Transgene Type:    Transgenic (Transposon concatemer)
Mutation:    Insertion
Mutation detailsA concatemer of sleeping beauty transposable elements each consisting of optimized inverted repeat direct repeat sequence specific for sleeping beauty transposase flanking splice acceptor sites (from engrailed-2) and poly A signals in both orientations. Between the splice acceptor sites is the sequence for the CAG promoter followed by a splice donor site. Two lines were created (lines 12740 and 12775) with 11 and 28 copies of the transgenic transposon concatemer inserted into chromosome 9 and 12, respectively. Line 12740 was selected as the representative line. (J:153656)
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:153656 Dupuy AJ, et al., A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res. 2009 Oct 15;69(20):8150-6
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory