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Id1tm3Bene
Targeted Allele Detail
Nomenclature
Symbol: Id1tm3Bene
Name: inhibitor of DNA binding 1, HLH protein; targeted mutation 3, Robert Benezra
MGI ID: MGI:4366910
Synonyms: Id1floxed, Id1L
Gene: Id1  Location: Chr2:152736251-152737410 bp, + strand  Genetic Position: Chr2, 75.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154023
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-neo-FRT cassette followed by a loxP site was inserted after the coding region of Id1. Another loxP was inserted before the Id1 gene such that the entire locus was floxed. This allele was generated by homologous recombination in Bruce4 ES cells. Southern blot positive ESC clones were injected into non-isogenic FVB blastocyts. Positive male chimeras were bred to B6J females. Black pups were screened by PCR genotyping and bred to B6 ACTB::FLPe mouse (Artemis Pharmaceuticals) to excise the neo cassette in vivo. (J:154023)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Id1 Mutation:  2 strains or lines available
References
Original:  J:154023 Nam HS, et al., High levels of Id1 expression define B1 type adult neural stem cells. Cell Stem Cell. 2009 Nov 6;5(5):515-26
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory