Dclre1c^tm2.1Jpdv
Targeted Allele Detail

Summary

• Symbol: Dclre1c^tm2.1Jpdv
• Name: DNA cross-link repair 1C; targeted mutation 2.1, Jean-Pierre de Villartay
• MGI ID: MGI:4366773
• Synonyms: Art^f
• Gene: Dclre1c Location: Chr2:3425168-3465167 bp, + strand Genetic Position: Chr2, 1.93 cM
• Alliance: Dclre1c^tm2.1Jpdv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153841
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 12, and a floxed neo cassette was inserted downstream of exon 12. Germ line, cre mediated recombination removes the neo cassette leaving exon 12 floxed. (J:153841)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dclre1c Mutation: 30 strains or lines available

References

• Original: J:153841 Rivera-Munoz P, et al., Reduced immunoglobulin class switch recombination in the absence of Artemis. Blood. 2009 Oct 22;114(17):3601-9
• All: 1 reference(s)