Pten^tm1.1Mwst
Targeted Allele Detail

Nomenclature

• Symbol: Pten^tm1.1Mwst
• Name: phosphatase and tensin homolog; targeted mutation 1.1, Michael Weinstein
• MGI ID: MGI:4366755
• Synonyms: Pten^loxP
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153747
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo allele was inserted downstream of exon 5. Transient cre expression mediated removal the neo cassette leaving exons 4 and 5 floxed. (J:153474)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 78 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Follicular Thyroid Carcinoma J:225245 (DOID:3962) in double homozygous Prkar1a and Pten conditional (Tg(TPO-cre)1Shk) mice.

References

• Original: J:153747 Trimboli AJ, et al., Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature. 2009 Oct 22;461(7267):1084-91
• All: 12 reference(s)