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Ptentm1.1Mwst
Targeted Allele Detail
Nomenclature
Symbol: Ptentm1.1Mwst
Name: phosphatase and tensin homolog; targeted mutation 1.1, Michael Weinstein
MGI ID: MGI:4366755
Synonyms: PtenloxP
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153747
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and a floxed neo allele was inserted downstream of exon 5. Transient cre expression mediated removal the neo cassette leaving exons 4 and 5 floxed. (J:153474)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  78 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Follicular Thyroid Carcinoma J:225245 (DOID:3962) in double homozygous Prkar1a and Pten conditional (Tg(TPO-cre)1Shk) mice.
References
Original:  J:153747 Trimboli AJ, et al., Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature. 2009 Oct 22;461(7267):1084-91
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory