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Targeted Allele Detail
Symbol: Bcl2l11tm1.1Boui
Name: BCL2-like 11 (apoptosis facilitator); targeted mutation 1.1, Philippe Bouillet
MGI ID: MGI:4366749
Synonyms: BimB, BimBad
Gene: Bcl2l11  Location: Chr2:128126038-128162547 bp, + strand  Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
Germline Transmission:  Earliest citation of germline transmission: J:153846
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe BH3 domain (in exon 5) was replaced by the mouse Bad BH3 domain by site-directed mutagenesis using PCR. A loxP-PGKneo-loxP cassette was inserted 840 bp downstream of exon 5. The neo cassette was removed by crossing the mice to cre deleter transgenic mice. (J:153846)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l11 Mutation:  14 strains or lines available
Original:  J:153846 Merino D, et al., The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol. 2009 Aug 10;186(3):355-62
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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