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Targeted Allele Detail
Symbol: Nanogtm1Jae
Name: Nanog homeobox; targeted mutation 1, Rudolph Jaenisch
MGI ID: MGI:4366292
Synonyms: Nanog-Luciferase reporter, NL
Gene: Nanog  Location: Chr6:122684448-122691592 bp, + strand  Genetic Position: Chr6, 57.8 cM, cytoband F2
Germline Transmission:  Earliest citation of germline transmission: J:153798
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 2 was replaced with a targeting vector including 1.2 kb of the Nanog promoter as a 5' arm, the firefly luciferase gene, SV40 polyadenylation signal sequence, loxP-flanked PGK-neo cassette, and 1.4 kb of intron 2 as a 3' arm. (J:153798)
Generation of the Nanogtm1Jae allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nanog Mutation:  44 strains or lines available
Original:  J:153798 Lyssiotis CA, et al., Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory