F2r^tm1Cgh
Targeted Allele Detail

Summary

• Symbol: F2r^tm1Cgh
• Name: coagulation factor II thrombin receptor; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:4366035
• Gene: F2r Location: Chr13:95738311-95754995 bp, - strand Genetic Position: Chr13, 50.21 cM
• Alliance: F2r^tm1Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71309
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The starting ATG codon as well as codons 2-4 of exon 1 were replaced with a lacZ-floxed PGKneo cassette. The neo cassette was in the same transcriptional orientation as the gene itself. Beta galactosidase staining is more intense when the neomycin cassette is left in place. (J:71309)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2r Mutation: 23 strains or lines available

References

• Original: J:71309 Griffin CT, et al., A role for thrombin receptor signaling in endothelial cells during embryonic development. Science. 2001 Aug 31;293(5535):1666-70
• All: 1 reference(s)