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Otx2tm11Asim
Targeted Allele Detail
Nomenclature
Symbol: Otx2tm11Asim
Name: orthodenticle homeobox 2; targeted mutation 11, Antonio Simeone
MGI ID: MGI:4365830
Synonyms: Otx2GFP
Gene: Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153562
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
    The coding region and 3'UTR were replaced with a GFP gene and floxed neo cassette. (J:153562)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 97 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  45 strains or lines available
References
Original:  J:153562 Acampora D, et al., Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory