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Otx2tm10Asim
Targeted Allele Detail
Nomenclature
Symbol: Otx2tm10Asim
Name: orthodenticle homolog 2; targeted mutation 10, Antonio Simeone
MGI ID: MGI:4365829
Synonyms: Otx2deltaCD
Gene: Otx2  Location: Chr14:48657679-48667644 bp, - strand  Genetic Position: Chr14, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153562
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsRegions containing the third and fourth transcriptional start sites were deleted and a floxed neo cassette was inserted in the downstream intron. The absence of protein expression of isoforms C and D was confirmed by western blot analysis. (J:153562)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  37 strains or lines available
References
Original:  J:153562 Acampora D, et al., Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory