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Targeted Allele Detail
Symbol: Otx2tm8Asim
Name: orthodenticle homeobox 2; targeted mutation 8, Antonio Simeone
MGI ID: MGI:4365827
Synonyms: Otx2deltaSS
Gene: Otx2  Location: Chr14:48657679-48667644 bp, - strand  Genetic Position: Chr14, 25.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:153562
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsThe splice site 119 bp upstream of the methionine translation initiation start codon was mutagenized and a floxed neo cassette was inserted into the downstream intron. Expression of isoforms A, B, C, and D is normal. (J:153562)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 13 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  40 strains or lines available
Original:  J:153562 Acampora D, et al., Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory