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Targeted Allele Detail
Symbol: Pvalbtm1(cre/ERT2)Zjh
Name: parvalbumin; targeted mutation 1, Z Josh Huang
MGI ID: MGI:4365738
Synonyms: Pv-CreER, PvCreERT2, Pv-CreERT2
Gene: Pvalb  Location: Chr15:78191114-78206400 bp, - strand  Genetic Position: Chr15, 36.93 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:151755
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Project Collection: Neuroscience Blueprint cre
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Pvalb (parvalbumin; also called PV or Pva) gene. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to remove the neo selection cassette. (J:151755)
 Tissue activity of this recombinase allele
Driver: Pvalb     Summary of all recombinase alleles driven by Pvalb. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pvalb Mutation:  24 strains or lines available
Original:  J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory