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Nkx3-1tm4(cre/ERT2)Mms
Targeted Allele Detail
Nomenclature
Symbol: Nkx3-1tm4(cre/ERT2)Mms
Name: NK3 homeobox 1; targeted mutation 4, Michael M Shen
MGI ID: MGI:4365630
Synonyms: Nkx3-1CreERT2
Gene: Nkx3-1  Location: Chr14:69190692-69194658 bp, + strand  Genetic Position: Chr14, 36.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153425
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA cre/ERT2-polyA sequence was inserted at the translation start site of the Nkx3-1 gene, thus generating a null allele. The targeting vector also contained a self-excising ACE-cre/PolII-neo selection cassette for positive selection and a PGK-tk (thymidine kinase) cassette for negative selection. The vector was transfected into TC-1 ES cells which were used to generate chimeras. Excision of the selection cassette occurred by passage through the male germline. (J:153425)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx3-1     Summary of all recombinase alleles driven by Nkx3-1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx3-1 Mutation:  20 strains or lines available
References
Original:  J:153425 Wang X, et al., A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature. 2009 Sep 24;461(7263):495-500
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory