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Ptpn11tm1.1Wbm
Targeted Allele Detail
Nomenclature
Symbol: Ptpn11tm1.1Wbm
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1.1, Walter Birchmeier
MGI ID: MGI:4365539
Synonyms: Ptpn11tm1.1Cbm, Shp2fl
Gene: Ptpn11  Location: Chr5:121130533-121191397 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153219
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. The neo cassette was removed by germ line, flp mediated recombination. (J:153219)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:  13 strains or lines available
References
Original:  J:153219 Grossmann KS, et al., The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16704-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory