Ern1^tm2.2Tiw
Targeted Allele Detail

Summary

• Symbol: Ern1^tm2.2Tiw
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 2.2, Takao Iwawaki
• MGI ID: MGI:4365398
• Synonyms: IRE1alpha^deltaR
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm2.2Tiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153222
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 20 and a frt flanked neo cassette and second loxP site were inserted downstream of exon 21 via homologous recombination. Flp and Cre mediated recombination then removed the neo cassette and exons 20 and 21. (J:153222)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 57 strains or lines available

References

• Original: J:153222 Iwawaki T, et al., Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
• All: 5 reference(s)