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Targeted Allele Detail
Symbol: Ern1tm2.2Tiw
Name: endoplasmic reticulum (ER) to nucleus signalling 1; targeted mutation 2.2, Takao Iwawaki
MGI ID: MGI:4365398
Synonyms: IRE1alphadeltaR
Gene: Ern1  Location: Chr11:106397620-106487796 bp, - strand  Genetic Position: Chr11, 69.14 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:153222
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 20 and a frt flanked neo cassette and second loxP site were inserted downstream of exon 21 via homologous recombination. Flp and Cre mediated recombination then removed the neo cassette and exons 20 and 21. (J:153222)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ern1 Mutation:  8 strains or lines available
Original:  J:153222 Iwawaki T, et al., Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory