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Targeted Allele Detail
Symbol: Ern1tm1Tiw
Name: endoplasmic reticulum (ER) to nucleus signalling 1; targeted mutation 1, Takao Iwawaki
MGI ID: MGI:4365396
Synonyms: IRE1alpha-
Gene: Ern1  Location: Chr11:106397620-106487796 bp, - strand  Genetic Position: Chr11, 69.14 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:153222
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette replaced exons 11 - 17 via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygous MEFs. (J:153222)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ern1 Mutation:  8 strains or lines available
Original:  J:153222 Iwawaki T, et al., Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory