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Mmp24tm1Otin
Targeted Allele Detail
Nomenclature
Symbol: Mmp24tm1Otin
Name: matrix metallopeptidase 24; targeted mutation 1, Carlos Lopez-Otin
MGI ID: MGI:4365393
Gene: Mmp24  Location: Chr2:155775342-155818366 bp, + strand  Genetic Position: Chr2, 77.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153230
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 5 and 6 were replaced with a neo cassette. Northern blot analysis confirmed the expression of a truncated transcript lacking enzymatic domains in the cerebellum. (J:153230)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp24 Mutation:  12 strains or lines available
References
Original:  J:153230 Folgueras AR, et al., Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16451-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory