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Ttc21btm2a(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Ttc21btm2a(KOMP)Wtsi
Name: tetratricopeptide repeat domain 21B; targeted mutation 2a, Wellcome Trust Sanger Institute
MGI ID: MGI:4364168
Synonyms: Ttc21btm1a(KOMP)Wtsi-lacZ
Gene: Ttc21b  Location: Chr2:66014671-66086961 bp, - strand  Genetic Position: Chr2, 39.08 cM
Alliance: Ttc21btm2a(KOMP)Wtsi page
IMPC: Ttc21b gene page
Mutation
origin
Mutant Cell Line:  EPD0041_2_E09
Germline Transmission:  Earliest citation of germline transmission: J:213263
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt1
 
Mutation detailsThe L1L2_gt1 cassette was inserted at position 66079515 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 66080377. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttc21b Mutation:  52 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory