Simc1^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Simc1^{tm1(KOMP)Wtsi}
• Name: SUMO-interacting motifs containing 1; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4363931
• Gene: Simc1 Location: Chr13:54651592-54699103 bp, + strand Genetic Position: Chr13, 28.74 cM
• IMPC: Simc1 gene page

Mutation origin

• Mutant Cell Lines: EPD0322_7_A02, EPD0322_7_E02, EPD0322_7_H03
• Germline Transmission: Unknown
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Pgk_P
• Mutation details: The insertion of the L1L2_Pgk_P cassette created a deletion of size 5355 starting at position 54671722 and ending at position 54677077 of Chromosome 13 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Simc1 Mutation: 58 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 2 reference(s)