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Lztfl1tm1e(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Lztfl1tm1e(KOMP)Wtsi
Name: leucine zipper transcription factor-like 1; targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID: MGI:4363232
Gene: Lztfl1  Location: Chr9:123694404-123717625 bp, - strand  Genetic Position: Chr9, 74.36 cM, cytoband F
Obesity, ventriculomegaly, and retinal degneration in Lztfl1tm1e(KOMP)Wtsi/Lztfl1tm1e(KOMP)Wtsi mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Lines:  EPD0264_2_B11, EPD0264_2_B12, EPD0264_2_D12, EPD0264_2_F11
Germline Transmission:  Earliest citation of germline transmission: J:226512
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Pgk_P
 
Mutation detailsThe L1L2_Pgk_P cassette was inserted at position 123711584 of Chromosome 9 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534, J:226512)
Generation of the Lztfl1tm1e(KOMP)Wtsi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Lztfl1 Mutation:  11 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory