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Cbx7tm1a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Cbx7tm1a(KOMP)Wtsi
Name: chromobox 7; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4363230
Gene: Cbx7  Location: Chr15:79915807-79971119 bp, - strand  Genetic Position: Chr15, 37.85 cM
Mutation
origin
Mutant Cell Lines:  EPD0013_1_B05, EPD0013_1_C05, EPD0013_1_F05, EPD0013_1_H05, EPD0018_1_A08, EPD0018_1_C09, EPD0018_1_D08, EPD0018_1_F07, EPD0018_1_G07, EPD0018_1_G08, EPD0018_1_G09, EPD0018_1_H07, EPD0018_1_H09 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 79921984 of Chromosome 15 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 79921094. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Cbx7 Mutation:  224 strains or lines available
Notes
Cell line EPD0018_1_D08 was successfully used to make chimeric mice. Germline transmission was accomplished. J:200082
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory