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Targeted Allele Detail
Symbol: Gmnntm1a(KOMP)Wtsi
Name: geminin; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4363191
Gene: Gmnn  Location: Chr13:24751845-24761923 bp, - strand  Genetic Position: Chr13, 10.64 cM
Mutant Cell Lines:  EPD0033_2_A06, EPD0033_2_A08, EPD0033_2_B06, EPD0033_2_B07, EPD0033_2_B08, EPD0033_2_C06, EPD0033_2_C07, EPD0033_2_C08, EPD0033_2_D07, EPD0033_2_D08, EPD0033_2_F07, EPD0033_2_F08, EPD0033_2_G08, EPD0033_2_H06, EPD0033_2_H07, EPD0033_2_H08 (Wellcome Trust Sanger Institute)
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
Mutation detailsThe L1L2_gt0 cassette was inserted at position 24757158 of Chromosome 13 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 24756351. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:148605, J:173534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 2 lines available
Carrying any Gmnn Mutation:  17 strains or lines available
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory