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Manealtm1a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Manealtm1a(KOMP)Wtsi
Name: mannosidase, endo-alpha-like; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4362994
Gene: Maneal  Location: Chr4:124855239-124862171 bp, - strand  Genetic Position: Chr4, 57.92 cM
Mutation
origin
Mutant Cell Lines:  EPD0026_3_B12, EPD0026_3_D11, EPD0026_3_E10, EPD0026_3_E11, EPD0026_3_E12, EPD0026_3_F10, EPD0026_3_F12, EPD0026_3_G10, EPD0026_3_H10, EPD0026_3_H12
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_st1
 
Mutation detailsThe L1L2_st1 cassette was inserted at position 124860918 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 124860076. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 4 lines available
Carrying any Maneal Mutation:  9 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory