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Myo10tm2(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Myo10tm2(KOMP)Wtsi
Name: myosin X; targeted mutation 2, Wellcome Trust Sanger Institute
MGI ID: MGI:4362966
Gene: Myo10  Location: Chr15:25622636-25813759 bp, + strand  Genetic Position: Chr15, 9.36 cM, cytoband C
Alliance: Myo10tm2(KOMP)Wtsi page
IMPC: Myo10 gene page
Mutation
origin
Mutant Cell Lines:  EPD0272_4_A10, EPD0272_4_A11, EPD0272_4_C10, EPD0272_4_C11, EPD0272_4_D10, EPD0272_4_E12, EPD0272_4_F10
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 9595 starting at position 25743960 and ending at position 25753555 of Chromosome 15 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 33 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Myo10 Mutation:  609 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory