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Nacadtm1(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Nacadtm1(KOMP)Wtsi
Name: NAC alpha domain containing; targeted mutation 1, Wellcome Trust Sanger Institute
MGI ID: MGI:4362585
Gene: Nacad  Location: Chr11:6547823-6556053 bp, - strand  Genetic Position: Chr11, 4.6 cM
Alliance: Nacadtm1(KOMP)Wtsi page
IMPC: Nacad gene page
Mutation
origin
Mutant Cell Lines:  EPD0319_1_A03, EPD0319_1_A04, EPD0319_1_A05, EPD0319_1_B05, EPD0319_1_C03, EPD0319_1_E01, EPD0319_1_E02, EPD0319_1_F02, EPD0319_1_G03, EPD0319_1_G04, EPD0319_1_G05, EPD0319_1_H01, EPD0319_1_H02, EPD0319_1_H05
Germline Transmission:  Earliest citation of germline transmission: J:211773
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 4102 starting at position 6548878 and ending at position 6552980 of Chromosome 11 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Nacad Mutation:  51 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory