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Baz1btm1a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Baz1btm1a(KOMP)Wtsi
Name: bromodomain adjacent to zinc finger domain, 1B; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4362304
Gene: Baz1b  Location: Chr5:135187323-135246131 bp, + strand  Genetic Position: Chr5, 75.05 cM
Mutation
origin
Mutant Cell Lines:  EPD0028_7_A01, EPD0028_7_A02, EPD0028_7_B02, EPD0028_7_C01, EPD0028_7_C02, EPD0028_7_D01, EPD0028_7_D02, EPD0028_7_D03, EPD0028_7_E01, EPD0028_7_E02, EPD0028_7_E03, EPD0028_7_F01, EPD0028_7_F02, EPD0028_7_F03, EPD0028_7_G01, EPD0028_7_G02, EPD0028_7_G03, EPD0028_7_H01, EPD0028_7_H03
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 135197724 of Chromosome 5 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 135198536. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 4 lines available
Carrying any Baz1b Mutation:  14 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory