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Atpaf2tm1a(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Atpaf2tm1a(KOMP)Wtsi
Name: ATP synthase mitochondrial F1 complex assembly factor 2; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4362266
Gene: Atpaf2  Location: Chr11:60400626-60418457 bp, - strand  Genetic Position: Chr11, 37.81 cM, cytoband B2
Mutation
origin
Mutant Cell Lines:  EPD0026_5_A01, EPD0026_5_B01, EPD0026_5_B02, EPD0026_5_C01, EPD0026_5_C02, EPD0026_5_C03, EPD0026_5_D02, EPD0026_5_D03, EPD0026_5_E01, EPD0026_5_E02, EPD0026_5_F01, EPD0026_5_F03, EPD0026_5_G02, EPD0026_5_G03, EPD0026_5_H01, EPD0026_5_H02, EPD0026_5_H03
Germline Transmission:  Earliest citation of germline transmission: J:175295
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 60407815 of Chromosome 11 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 60407009. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 2 lines available
Carrying any Atpaf2 Mutation:  13 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory